10102-18-8): Listed for SARA Section 313 Chemicals: (Selenium Compounds- SARA 313) Toxic Substances subject to annual release reporting requirements listed at 40 CFR 372.65. Common Name: SODIUM SELENATE CAS Number: 13410-01- DOT Number: UN 2630 ----- HAZARD SUMMARY * Sodium Selenate can affect you when breathed in and may be absorbed through the skin. from inhalation exposure, sodium selenite to have extreme toxicity from oral exposure, and elemental selenium to have low toxicity from oral exposure. These are white, water-soluble solids. Disodium selenite pentahydrate is a hydrate that is the pentahydrate form of disodium selenite. MSDS Name: Sodium Selenite, Anhydrous, 44-46% se Catalog Numbers: AC200730000, AC200730250, AC200731000 Synonyms: Disodium Selenite; Selenious Acid Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 Furthermore, it can damage the heart, liver, eyes, kidneys, and other organs, raising the risk of diabetes and even cancer. In cats, selenium toxicity can cause hair and coat loss, brittle nails, digestive disturbances, skin rashes, and nervous disorders. In animals, the minimum lethal dose for intravenous administration of sodium selenite is between 1.5 and 3 mg/kg [22, 23]. WGK 2. The crystal structure of the anhydrous salt has been variously reported as tetragonal or monoclinic. 172.94 g/mol. IDENTIFICATION. * Contact can severely irritate and burn the skin and eyes with possible eye damage. * Contact can severely irritate and burn the skin and eyes with possible eye damage. Investigations on the role of base excision repair and non-homologous end-joining pathways in sodium selenite-induced toxicity and mutagenicity in Saccharomyces cerevisiae. The purpose of this study was to investigate the acute toxicity of sodium selenite in mice and rats after per os application to establish the relationship between a high toxic dose of sodium selenite and tissue alterations in rats. In contrast, sodium selenite did not break DNA (lane 2) unless it was mixed with glutathione (lane 4), . Sodium selenite is an ingredient found in roughly 90% of all commercial pet foods. The bioactivities and toxicities of inorganic sodium selenite, organic selenomethionine (SeMet), and Se-methylselenocysteine (SeMSC) have been extensively investigated. European Inventory of Existing Chemicals (EINECS) EC Classification Sodium selenate is the inorganic compound with the formula Na 2 SeO 4, not to be confused with sodium selenite.It exists as the anhydrous salt, the heptahydrate, and the decahydrate. Boosts Immune System | Helps Break Down and Reduce Toxic Metals | 96 Servings | 8 fl oz. Sodium selenite is the most toxic compound when ingested orally. SARA 302/304/311/312 extremely hazardous substances: Sodium selenite SARA 313 toxic chemical notification and release reporting: Sodium selenite CERCLA: Hazardous substances. Selenium sulfide has been linked with the occurrence of liver and lung tumors in mice and rats following oral exposure. Hazardous Reactions None under normal processing. * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. NA-SEIT-02-C.5HYD , NA-SEIT-03-C.5HYD , NA-SEIT-04-C.5HYD , NA-SEIT-05-C.5HYD CAS #: 26970-82-1 Relevant identified uses of the substance: Scientific research and development Supplier details: American Elements 10884 Weyburn Ave. In contrast, sodium selenite did not break DNA (lane 2) unless it was mixed with glutathione (lane 4), . Two of 3 groups of castrated Landrace pigs, weighing 23.5 4.6 kg and anaesthetized with nitrous oxide and methoxyflurane received i.v. Mutagenesis. Acute toxicity, Oral (Category 1, 2), H300 Sensitization, Skin (Category 1) H317 Acute toxicity, Inhalation (Category 3), H331 Chronic aquatic toxicity . Repeated or prolonged exposure to the substance can produce target organs damage. . SELENITE, SODIUM : figure/table : figures and tables of selenium concentration over time (% of administered dose) . Chat now for more business. The ingredient is even utilized as a selling point, which is very strange to say the least given its toxic properties. Read-across from sodium selenite and selenious acid to barium/zinc selenite Based on a comparison between toxicity reference values of zinc compounds and selenium compounds, it can safely be assumed that the selenium/selenite moiety of zinc selenite is generally of higher toxicological relevance than the zinc cations. Available data suggest that humans excrete selenium compounds in a . However, elevated concentrations of Se in the body can also cause oxidative stress. Both compounds have been found in chemical waste sites. These chemicals are used in food & beverage and pharmaceutical industries. The toxicity depends on the molecular form. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. . (1,3) . : Sodium selenite: 100 lbs. Too much selenium -- more than 400 micrograms per day -- causes selenosis, a toxicity linked to bad breath, skin rashes and abnormal function of the nervous system. Abstract. . Author(s) Fairbrother, A. and J. Fowles. Prop 65 - Developmental toxicity Substance is not listed. Handle with extreme caution. TOX-38 Toxicity Studies of Sodium Selenate and Sodium Selenite (CASRNs 13410-01- and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1Mice. In one study, sodium selenite was found to induce substantial DNA damage in human fibroblasts. Product Name: Sodium Selenite Pentahydrate Product Number: All applicable American Elements product codes, e.g. Pages. What's worse, the mineral's toxicity also seems to be related to the chemical form used to make a each recipe. * Sodium Selenite may cause mutations. Sodium selenite is a colorless toxic solid. Repeated or prolonged exposure to the substance can produce target organs damage. According to the 1986 edition of the Handbook of the Toxicology of Metals, daily intake of about one milligram of selenium as selenite can be toxic. In contrast, selenocompounds, especially sodium selenite, can display pro-oxidant properties that may be toxic [19, 20]. The heaviest concentration . Prop 65 - Developmental toxicity, female Substance is not listed. According to the classification standard of acute toxicity, sodium selenite belongs to the category 5 (highly toxicity). A broad category of chemical actions with harmful or deadly effect on living organisms. Year . Common Name: SODIUM SELENITE CAS Number: 10102-18-8 DOT Number: UN 2630 ----- HAZARD SUMMARY * Sodium Selenite can affect you when breathed in and by . Not Reported : Toxicity Factor Datasets : Laboratory : Citation: Subchronic effects of sodium selenite and selenomethionine on several immune functions in mallards. Arterial blood was taken before dosing and at 60 and 120 minutes when the pigs were killed. In extreme selenosis cirrhosis of the liver, pulmonary edema, or even death can occur. 61.15.1.3 Toxicity to Humans Accidental and Intentional Poisoning Apparently there is no record of human poisoning by sodium selenate. During pregnancy, a low Se status can increase the risk of oxidative stress. The chronic oral toxicity of sodium selenite has been evaluated in several laboratory species. Dose limiting toxicities (DLTs) of the combination of sodium selenite plus abiraterone are defined as: Any Grade 3 non-hematologic toxicity (possibly, probably, or definitely-related adverse event) Any Grade 3 thrombocytopenia with bleeding Any Grade 4 thrombocytopenia persisting > 7 days Any Grade 4 neutropenia persisting > 7 days Flash Point(F) Not applicable . As a result . Aquatic toxicity: 10102-18-8 sodium selenite Oral LC50 / 96 h 2.75 mg/L (Oncorhynchus mykiss) Sodium selenite is toxic in high concentrations. The best protection is to Formulating pig diets: Selenium toxicity, deficiency . The US Institute of Medicine set the adult Tolerable upper intake limits (UL) for selenium from all sources - food, drinking water, and dietary supplements - at 400 g/day in 2000. . There was no evidence of teratogenicity in guinea pigs, mice, or rats. Signs and Symptoms of Sodium Selenite Exposure: Signs and symptoms of acute sodium selenite exposure include the following: garlic odor on breath, drooling, nasal irritation and burning sensation in nostrils, vomiting, hypotension . . sodium selenite 10102-18-8 >99 . Sodium selenite can be controversial substance when it's used in a dog food recipe. Considerations and Risks While selenium supplements offer a wealth of potential benefits, you should only take them under medical supervision. In contrast, selenized yeast appears to have a higher selenium bioavailability than sodium selenite. "Sodium selenite may be toxic to blood, kidneys, liver, skin, central nervous system. Lastly, it is essential to know that you should not use selenite damaged by water or saltwater, as the stone no longer has its beneficial properties. Toxicological information Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Sodium selenite LD50 = 7 mg/kg ( Rat ) Not listed Not . Elimination (mostly in the urine) results in a biological half-life of around 1.2 days. Ionic Selenium Supplement 100ml | Contains Selenium in The Form of Sodium Selenate | Easy to Consume Selenium Liquid | Only Active Ingredients & Purified Water . Typical therapeutic dosage is in the range of 10-30 mg per day. Vigasov D, et al. More soluble compounds, for example, sodium selenite, are more toxic than the less soluble elemental selenium, selenium sulfide, or selenium disulfide. Se toxicity lead to a condition called selenosis i.e., garlic odor of the breath, gastrointestinal disorders, hair loss, sloughing of nails, and neurological damage. Summary of experiments to determine the toxicity of single doses of selenium in the form of sodium selenite administered orally to horseSy muleSj cattle, and swine Species and No. Selenite is non-toxic. More recent research also indicates that too much selenium may contribute to the onset of diabetes." Sodium selenite appears as a white colored crystalline solid. Results and conclusion: MTD was defined as 10.2 mg/m(2), with a calculated median plasma half-life of 18.25 h. The maximum plasma concentration of selenium from a single dose of selenite increased . P362+364 Take off contaminated clothing and wash it before reuse. Administration of sodium selenite can be sublingual, swallowed or by IV injection. [Abstract] Study Data Protocol Toxicity and Carcinogenicity Studies 3-Month Evaluation of the Toxicity (C04308) of Sodium Selenite (10102-18-8) in F344/N Rats Exposed via Dosed Water It contains a disodium selenite. To formulate the chemicals, we use finest quality of compounds, procured from the most reputed and trusted vendors. Why is selenite toxic? Excesses of any form of selenium can be toxic but there is a very safe dosage range where sodium selenite can treat cancer without any adverse side effects or toxicity. Brand. Toxicity causes selenosis, with symptoms including fatigue, irritability, hair loss, garlic breath odor, mild nerve damage, white . Sodium selenite is the inorganic compound with the formula Na2SeO3. The secondary endpoint was primary response evaluation. Similarly, a human has a 50% chance of dying after consuming only 108 milligrams. (EPA, 1998) . CAMEO Chemicals Safety Data Sheet (SDS) for Sodium Selenite Revision Date: Jan 07, 2016 Version: A/1 4 / 15 P333+P313 If skin irritation or rash occurs: Get medical advice/attention. Based on the preceding review, the optimal form of Se for nutritional supplementation and cancer prevention would be expected to have distinctly low toxicity and to possess good . Toxicity of Selenium was significantly higher in exponentially growing cells than in cells in the stationary phase . However, some studies in rats suggested that Sodium Selenite was 2.94 times more toxic than an alternative form of Selenium called Selenium Yeast. Stable in air. Contact China Manufactory Henan Tianfu Chemical Co.,ltd for the product Sodium selenite, 99%. The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. Muscle tenderness, tremor, light- headedness and facial flushings are observed in selenite poisoning. [7] In 2000, the U.S. Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 g/day. | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on TOXIC ACTIONS. Soluble in water and more dense than water. This often consumed byproduct is known as sodium selenate, and is capable of killing 50% of rats who ingest as little as .4 milligrams of it. Laboratory Findings Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) Sodium selenite is a salt; a selenium compound that is water-soluble. Meanwhile, the acute toxicity test results of bio-Se obtained from yeast were shown in Table 2. Sodium selenite significantly increases TBARS production (about 11.421.31pmol TBARS/mg protein compared to about 40.21 pmol TBARS/mg protein).The magnitude of increase was more than 3-fold at 5 mmol relative to the control. The National Institute of Health states that toxicity is very rare for sodium selenite. Increasing doses of sodium selenite (4, 10, 14 and 18 mg/kg) were administered in separate groups of mice and rats. Ingestion of about 1000 mg of sodium selenite caused a condition similar to arsenic poisoning with death in 5 hr (Moeschlin, 1965 ). 2 mg selenium/kg in 7.5 ml saline as, respectively, sodium selenite or dimethylselenide. Live weight Dosage of Method of administration Selenium as sodium selenite per pound of body weight Result Sodium selenite Water Horse: 775 14.22 764 875 Pounds 1,185 970 Thus, LD 50 of sodium selenite was calculated to be 21.17 mg/kg. The chronic toxic dose of selenium as Sodium Selenite for humans was estimated to be between 2.4 and 3 mg per day. Don't take my word for it, you can click on this link and read an actual MSDS 836-844. * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. (Sodium Selenite) DATE PREPARED: 10/13/2015 Page 7 of 8 SARA Section 313: Sodium Selenite (CAS No. Contact may irritate skin, eyes and mucous membranes. Selenium dioxide is highly to moderately toxic, with oral LD50 values in rodents from 20 to 70 mg kg 1. Unfortunately, there have not been identical studies done on dogs to see if that is also the case for them, so it's difficult to know if we can make assumptions based on this. 11. Sodium selenite caused increases in NADP isocitric-dehydrogenase (NADP-ICDH . I think you might be confusing sodium selenite (the ion) with selenite (the mineral). The need for supplemental selenium in U.S. pig diets is largely dependent on the soil type in which the corn and soybeans are grown for inclusion in pig diets. [8] That's because although the mineral is essential for normal cell function in all animals, selenium can be toxic in high doses. Sodium selenite Revision Date 24-Dec-2021 Hazardous Polymerization Hazardous polymerization does not occur. Based on our research, I would prefer that Se be 50 percent sodium selenite and 50 percent organically-derived (e.g., Sel-Plex). In one study, male and female Wistar rats were given dietary sodium selenite at concentrations of 0, 0.5, and 2.0 ppm in a semipurified high-protein diet for an entire lifetime (Tinsley et al., 1967; Harr et al., 1967). Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. Animal studies have reported that selenium supplementation, as sodium selenate, sodium selenite, and organic forms of selenium, results in a reduced incidence of several tumor types. It is considered an indispensible trace mineral. 2010; 25:155-162. Several lines of evidence show epigallocatechin-3-gallate (EGCG), a predominant component of green tea catechins with numerous health benefits, can ameliorate the toxicity of many agents. 3, 8 selenium presents a nutritional conundrum because of its dual status as an essential but The primary endpoint was safety, dose-limiting toxic effects and the MTD of sodium selenite. It has a role as a nutraceutical. . . The decahydrate is a common ingredient in multivitamins and livestock feed as a source of selenium. Thirteen-week toxicity studies were conducted by administering the chemicals to groups of male and female F344/N rats and B6C3F1 . In a Cochrane review of selenium and cancer prevention studies, compared with the lowest category of selenium intake, the highest intake category had a 31% lower cancer risk and 45% lower cancer mortality risk as well as a 33% lower risk of bladder cancer and, in men, 22% lower risk of prostate cancer [ 37 ]. The best . It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE. The anhydrous salt is used in the production of some glass. Indeed, selenium was initially known as a toxic element in animal poisoning by selenium-rich plants . Safe Storage (GHS): P403+P233 Store in a wellventilated place.. Keep container tightly clos This salt is a colourless solid. * Sodium Selenite may cause mutations. Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. Prop 65 - Developmental toxicity, male Substance . Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) Toxic by ingestion, inhalation and skin absorption. The pentahydrate Na2SeO3(H2O)5 is the most common water-soluble selenium compound. . P391 Collect spillage. excessive doses of selenium result in intoxication, which is characterised by continuous vomiting, garlicky breath, mucosal irritation, abdominal pain, hypersalivation, haemolysis, necrosis of the liver, cerebral and pulmonary oedema, coma and death. This method is a simple, low cost green synthesis alternative to chemical synthesis. Sodium selenite 99%; CAS Number: 10102-18-8; EC Number: 233-267-9; Linear Formula: Na2SeO3; find Sigma-Aldrich-214485 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich . The potential reproductive toxicity of Sodium (Sodium Selenite Pentahydrate) nitrite exposure restricted to the prenatal period has been reported in guinea pigs, mice, and rats. Initiated in the year 1985, we are a leading manufacturer and supplier of Sodium Selenite. Sodium selenite "may be toxic to blood, kidneys, liver, skin, central nervous system. At high or toxic levels as much as 30 to 60% of selenium can be excreted via expired air , predominantly as dimethylselenide. 1 and 2 / very toxic hazardous materials. Handle with extreme caution. View Article This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin . Sodium selenite and sodium selenate have also been approved as feed additives at a maximum concentration of 0.5 mg selenium/kg feed (complete feed). EINECS: This product is on the When heated to decomposition, may emit toxic fumes of selenium and sodium oxide. Both the acid and elemental form are well absorbed through the lungs and gastro-intestinal tract. So - if your cows . WGK. Maruti Chemicals. SECTION 1. Statistical results of acute toxicity test for sodium selenite. Sodium selenate and sodium selenite are used as supplements to poultry and livestock feed to promote growth and prevent selenium deficiency diseases. Also, it is mainly used in the manufacture of colorless . Furthermore, saltwater will damage selenite even more, as salt is corrosive and highly abrasive on stones like selenite. However, Sodium (Sodium Selenite Pentahydrate) nitrite treatment of pregnant guinea pigs with 60 . 6.1B - Non-combustible, acute toxic Cat. Molecular Weight. The high conversion of selenium ions to selenium nanoparticles (SeNPs) was achieved by a reaction mixture of 0.1 g bovine serum albumin and 0.1 g sodium selenite at a reaction temperature of 121C for 20 min duration. 8 Fl Oz (Pack of 1) 4.4 out of 5 stars 298 . (45.36 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). The disodium salt of selenious acid. Investigations on the role of base excision repair and non-homologous end-joining pathways in sodium selenite-induced toxicity and mutagenicity in Saccharomyces cerevisiae. Abstract Selenium, an essential trace element, can also be toxic at higher levels of exposure. When an overload of selenium (in its natural or artificial form) accumulates in the body, it can also cause damage to the heart, liver, eyes, kidneys, may contribute to the onset of diabetes and even be carcinogenic. Because selenium is an essential element, it is mainly used in feed additives and food industry. Sodium selenite (Na 2 SeO 3) is a toxic inorganic salt that is highly soluble in water and insoluble in organic solvents. SARA Section 313 (specific toxic chemical listings) 10102-18-8 Sodium selenite California Proposition 65 Prop 65 - Chemicals known to cause cancer Substance is not listed. Although plants in some parts of the country can contain toxic levels of Se, forages grown in many parts of the country do not contain adequate levels of Se for optimum animal performance. 1-48 of 132 results for "sodium selenite" RESULTS. . Mutagenesis 25: 155-162.